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  • High Performing Individuals

  • Sharp Focus & Regaining Consciousness

  • Individuals looking for an Unfair Advantage over their peers.

 Guide to cognitive Performance | Pharm Biotics

Waking up with Brain Fog? It’s a wake-up call!

Want to take control over your mental capacity? Then this guide might be perfect for you. I wrote this with my extensive experience just to help individuals like you with the research knowledge available today. First, I will be talking about the science behind Mental Energy so stick with me. Some days are difficult and you feel slumped in the mornings, which you fix with a cup of coffee or quick bath but constant lack of energy, a struggle to get out of bed & combating the urge to fall asleep at your desk is a matter of concern. One can have a depressed mood most of the day & may have a little interest in normal activities. A lack of energy can lead to – fatigue, lack of focus, overeating or lack of appetite, over or under sleep, feel hopeless and worthless etc. If an individual experiences these emotional, cognitive, physical and behavioural alterations it’s a wake-up call & should be taken seriously. Waking up with Brain Fog? It’s a wake-up call!


How your Mental Health Is Affecting Your Cognitive Performance

Depression and anxiety can be the root cause of fatigue and hinder the ability to feel energized and focused. Therefore, leads to disruptions in work/family/social life and common daily activities, thus leading to a substantial reduction in the quality of life. Going to work becomes difficult and stressful, a social withdrawal that affects self-esteem in individuals. According to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-V), anxiety disorders are classified into generalized anxiety disorder, panic disorder, specific or social phobias and social anxiety disorder (SAD). The wide range of symptoms includes difficulty in concentrating, restlessness, irritability, fear, feelings of hopelessness, low self-esteem, lack of energy/tiredness and insomnia (lack of sleep). Depressive disorders can be classified into disruptive mood dysregulation disorder (MDD), persistent depressive disorder (dysthymia), premenstrual dysphoric disorder, substance/medication-induced depressive disorder, other specified/unspecified depressive disorder. Thus, it is important to get over the Mental Health Barrier in order to improve your cognitive performance & capacity.

 Depression & Anxiety

Pathophysiology of Anxiety & Depression: Alteration of Neurobiological System

Neuroendocrine studies demonstrate that fear is activated in the amygdala, a key component of the limbic system which leads to increased levels of serotonin and increased sympathetic nervous activity with subsequent increases in norepinephrine and serotonin which in turn leads to a feeling of anxiety. Also, hyperactivity of the amygdala and hypothalamus increases corticotropic-releasing hormone (CRH). Elevated CRH is highly implicated in anxiety and depression.

It hyper activates the Hypothalamus Pituitary Adrenal (HPA) axis’s dynamic responsiveness to stress which results in high cortisol level and alter cortisol circadian rhythm. This elevation of cortisol ultimately results in reduced sensitivity to negative feedback on the part of the hypothalamus and pituitary. This perpetuates the sustained elevation of CRH and resultant anxiety. Hence, the HPA axis, limbic system, neurotransmitters and other components of the neurobiological system alters anxiety and depression which needs to be targeted in treatment. The key is to control anxiety & depression in order to unlock an improved cognitive performance.


How To Stop Feeling Tired

Many cases of exhaustion are caused by stress, a lack of sleep, a poor diet, and other lifestyle factors. To regain your energy, try these self-help tips.

You may have an underlying medical condition if you experience fatigue, which is an overwhelming tiredness that isn't relieved by rest and sleep. Seek advice from your primary care physician. You must be wondering how to stop feeling tired, below are some changes you can make to your lifestyle in order to stop feeling tired.

Rest Well

Many people do not get enough sleep to stay alert during the day.

Here are some suggestions for getting a good night's sleep:

  • Going to bed and getting up at the same time every day..
  • Avoiding naps during the day taking time to relax before bed.
  • Learn more about getting a good night's sleep here.

Reduce Stress to Increase Energy

Stress consumes a lot of energy. Incorporate relaxing activities into your daily routine. This could be something like:

exercising at the gym
yoga or tai chi listening to music or reading socialising with friends
Whatever you do to unwind will boost your energy.

Learn more about how to deal with stress.


Mood Enhancement & Uplifting = Boosted Cognitive Performance

A good sleep, balanced diet, good health (physical and mental) & calm environment promotes mental sharpness and productivity all day long. It brightens the day and mood and energizes everyday life. In this fast pace life, performance pressure and maintaining socioeconomic level several times the biological clock is unheard and professionals, several individuals work around the clock and suffer from insomnia, fatigue, lost focus, unable to concentrate eventually caught with anxiety and depression. Few individuals fall prey to stimulant drugs or high doses of caffeine to keep with the competitive world. Long term fix would be to improve your lifestyle & introducing natural supplements to your diet.

Energy Drops | Nootropics | CBD
Energy Drops: Formulation for an Unfair Advantage

Supercharging of mood can be achieved naturally by using Energy drops which are easily available & do not require a prescription. Energy drops have strong mood uplifting & cognitive performance boosting properties. What makes Energy Drops unique? The Energy drops have been formulated using the most potent natural ingredients blended together. It constitutes the following extracts:

Pharm Biotics CBD
1) Pure CBD

It is one of the cannabinoids extracted from cannabis and hemp plants play a significant role in the regulation of anxiety and depression-related disorders and cognitive behaviour. Cannabinoids play a major role in promoting a calming & relaxing effect.

CBD is non-psychoactive and non-impairing (won’t get you high). CBD used to formulate Energy Drops is concentrated, hence it is pure CBD and free from other cannabinoids with absolutely zero impurity.


CBD interacts with the endocannabinoid system (consist of endogenous lipid based retrograde neurotransmitters endocannabinoids and cannabinoid receptors proteins found all over the body (brain, immune cells, connective tissue, glands and immune cells) reduces anxiety and depression and effectively cause a calm and relaxed state.


Pharm Biotics CBD Ashwagandha Drops


2) Ashwagandha (Withania somnifera)

Ashwagandha (Withania somnifera) is an adaptogenic herb that increases dopamine receptors in the brain reduces the anxiety producing effects of norepinephrine while boosting an individual’s capability of focusing & concentrating. Please find a detailed description of Ashwagandha & it's effects in the next section.


Pharm Biotics CBD Guarana Drops

3) Guarana (Paullina cupana)

Extract of seeds of Guarana (Paullinia cupana) is rich in caffeine, theophylline & theobromine. It offers an immediate energizing effect. It improves cognitive performance and reduce the mental fatigue associated with sustained mental effort, Reducing Fatigue, Improve Focus, Enhancing Mood & Improving Overall Cognitive Performance.

Pharm Biotics CBD Energy Drops

4) Terpology® Focus

Terpology Focus Terpene Blend is based on a foundation of mind-clearing alpha pinene and the even-keel of linalool to create a balance between stimulation and calmness. The other components share a common thread with essential oils to help facilitate concentration. Focus Terpene Blend is based on a foundation of mind-clearing alpha pinene and the even-keel of linalool to create a balance between stimulation and calmness. The other components share a common thread with essential oils to help facilitate concentration.

Pharm Biotics CBD Energy Drops | MCT oil
5) MCT Oil (Medium Chain Triglycerides)

It is Medium Chain Triglyceride oil extracted from coconut oil. Being lipid like fatty acid it has been used as a career for CBD (fat soluble compound) to facilitates CBDs absorption hence increases the bioavailability of CBD to the body.


Ashwagandha for Anxiety: Is it safe to use?

The capacity of ashwagandha to decrease cortisol, the stress hormone, is perhaps its most well-known impact. In a small placebo-controlled trial on ashwagandha supplements conducted in 2014, doses as little as 250 mg daily for 60 days substantially decreased self-reported anxiety levels as well as blood cortisol levels.

Ashwagandha For Anxiety: The relationship

Despite Ashwagandha's lengthy history of medical usage, research is just now starting to discover some of its potential advantages. One of the most highly anticipated benefits is its potential to reduce the physical and psychological consequences of chronic stress. The capacity of ashwagandha to decrease cortisol, the stress hormone, is perhaps its most well-known impact. In a small placebo-controlled trial on ashwagandha supplements conducted in 2014, doses as little as 250 mg daily for 60 days substantially decreased self-reported anxiety levels as well as blood cortisol levels (Auddy, 2008).

While cortisol is necessary for critical processes such as metabolism, persistently high amounts of this hormone may lead to additional concerns such as blood sugar imbalances and weight gain. As a result, supplementing with Withania somnifera to lower cortisol levels is a potentially beneficial medicinal application of the plant. Ashwagandha for anxiety works on theoretical level based on the research we have available today.

Ashwagandha For Anxiety: Beyond cortisol levels, ashwagandha may help with anxiety.

An previous research of safety discovered the same effect in individuals who were under a lot of stress. All participants self-scored at 14 or higher on a perceived stress scale (PSS) ranging from 0 (no stress) to 40 (extreme stress). After 60 days, the placebo group's PSS had decreased by an average of 5.5 percent, while those who supplemented twice a day with full-spectrum ashwagandha root extract showed a 44 percent reduction in their self-reported stress score (Chandrasekhar, 2012).

However, these researchers did not stop there. Along the process, they had participants fill out depression anxiety stress scale (DASS) questionnaires, which categorises individuals' worries. This allowed researchers to compare how individuals felt about sadness, anxiety, and stress before and after treatment with the medicinal plant. Their findings demonstrated that the adaptogenic plant lived up to the hype, providing both an anti-depressive and anxiolytic (anti-anxiety) effect. There was a substantial decrease in all categories by day 60: 77 percent for depression, 64.2 percent for stress, and 75.6 percent for anxiety. Of course, this was just one study, and establishing if ashwagandha really has these benefits would require further research.

It may also be effective in decreasing stress in more severe instances. Ashwagandha substantially aided individuals in a randomised double-blind trial with ICD-10 anxiety disorders, such as generalised anxiety disorder (GAD), mixed anxiety and depression, panic disorder, and adjustment disorder with anxiety, in the therapy group (Andrade, 2000). These illnesses are often treated with a mix of treatment and prescription medicine, but the power of herbal alternatives should not be underestimated. In fact, therapy with Withania somnifera glycowithanolides, potent chemicals derived from ashwagandha root, was shown to be as efficient as lorazepam in an animal research (Bhattacharya, 2000).

That isn't to suggest ashwagandha is a panacea for worry. One research compared the effectiveness of conventional psychotherapy intervention (PT) against naturopathic treatment in reducing anxiety (NC). Deep breathing exercises were taught to both groups. Psychotherapy and a placebo pill were given to the PT group, whereas dietary counselling, a multivitamin, and ashwagandha were given to the NC group. The adaptogenic benefits were evident after at least eight weeks of treatment: self-reported anxiety had decreased by 30.5 percent in the PT group and 56.5 percent in the NC group (Cooley, 2009). Other variables were involved, but the research provides optimism and a scientific foundation to think that ashwagandha extract may be a useful component of a comprehensive therapy strategy to alleviate anxiety and improve general mental health, therefore making Ashwagandha for anxiety, an optimistic choice backed by sophisticated measures.


"You will notice a boost in your overall performance whether it be - physical performance at the gym, mental performance at work or just spiritually as a person." - Pharm Biotics


Recommendation: It is advisable to consult your health care professional before starting of any kind of supplements or pharmaceutical or plant-based medication.

Dr Devendra Ridhurkar | Pharm Biotics

written by Dr. Devendra Ridhurkar, PhD (Pharmaceutics)

Dr. Devendra works as an Expert Scientist-Formulation and Development at Neurax Pharm., Barcelona, Spain. He is responsible for the development of innovative formulations. He has over 16 years of experience and was associated with various pharma giants, Egis, Hungary, Dr Reddy’s, India to name a few. He is an expert in using platform technologies like hot-melt extrusion (HME), gastroretentive drug delivery systems, nanotechnology and cyclodextrin complexation. He obtained his M. Pharm & PhD degree in Pharmaceutics from IIT, BHU, Varanasi, India. He is a member of the editorial board of peer pharmaceutical journals and has earned over 8 peer-reviewed papers in various international and national journals and 5 patents to his credit. He has been associated with various pharmaceutical bodies in the Indian and American Association of Pharmaceutical Scientists. He is a member of the program advisory committee for Pharma Connect Congress, Hungary and has presented his research work in several international congresses and scientific meetings.



References (Clinical Evidences included) 481.pdf R